Symbol
Name
ID

Flt3
FMS-like tyrosine kinase 3
MGI:95559

Phenotype annotations related to hematopoietic system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias	Acute myeloid leukemia	Lymphoma
Disease(s) Associated with FLT3	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemias	Acute myeloid leukemia	Lymphoma
acute lymphoblastic leukemia
acute myeloid leukemia

Mouse Phenotypes

enlarged spleen

abnormal hematopoietic system morphology/development

abnormal definitive hematopoiesis

abnormal common myeloid progenitor cell morphology

abnormal B cell differentiation

increased pre-pro B cell number

decreased pro-B cell number

increased pro-B cell number

arrested B cell differentiation

abnormal myelopoiesis

myeloid hyperplasia

extramedullary hematopoiesis

abnormal bone marrow cell morphology/development

abnormal bone marrow cell number

decreased bone marrow cell number

increased bone marrow cell number

decreased megakaryocyte cell number

increased megakaryocyte cell number

decreased erythrocyte cell number

decreased hemoglobin content

decreased neutrophil cell number

increased neutrophil cell number

increased granulocyte number

thrombocytosis

decreased plasmacytoid dendritic cell number

decreased dendritic cell number

increased dendritic cell number

decreased mature B cell number

decreased B cell number

decreased pre-B cell number

decreased NK cell number

decreased effector memory T-helper cell number

decreased T cell number

decreased lymphocyte cell number

increased monocyte cell number

decreased leukocyte cell number

increased leukocyte cell number

increased hematopoietic stem cell number

abnormal B cell morphology

abnormal spleen morphology

increased spleen red pulp amount

intermingled spleen red and white pulp

abnormal spleen white pulp morphology

increased spleen white pulp amount

decreased splenocyte number

abnormal NK cell physiology

abnormal macrophage physiology

abnormal bone marrow cell physiology

Availability

Mouse Genotype

Flt3^{em1(IMPC)Ccpcz}/Flt3^{em1(IMPC)Ccpcz}

Flt3^m1Btlr/Flt3^m1Btlr

Flt3^tm1Dgg/Flt3^tm1Dgg

Flt3^tm1Irl/Flt3^tm1Irl

Flt3^tm1.1Dosm/Flt3⁺

Flt3^tm1Dgg/Flt3⁺

Flt3^tm2.1Dosm/Flt3⁺

Flt3^tm1Dosm/Flt3⁺
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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